Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 2004

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

The effect of combination therapy with metformin and combined oral

contraceptives (COC) versus COC alone on insulin sensitivity,

hyperandrogenaemia, SHBG and lipids in PCOS patients.

AUTHORS

Cibula D; Fanta M; Vrbikova J; Stanicka S; Dvorakova K

SOURCE

Human Reproduction. 2004;20(1):180-184.

ABSTRACT

Neither oral contraceptives (COC) nor metformin are an optimal modality for the long-term treatment of polycystic ovary

syndrome (PCOS). The aim of this study was to evaluate whether a combination of both is beneficial over COC

monotherapy. Altogether, 30 women were included in the study and 28 finished the protocol. The patients were

randomly assigned to two groups treated with either COC (COC group) or COC and metformin (1500 mg/day) (METOC

group) for 6 months. Anthropometric parameters, androgens, lipids, fasting insulin, glucose and sex hormone binding

globulin (SHBG) concentrations were measured before and at the end of the sixth cycle of treatment. The insulin

sensitivity index was evaluated using the euglycaemic clamp. There were no significant changes in anthropometric

parameters, fasting glucose or insulin sensitivity in either group. Total testosterone, free androgen index,

androstenedione and dehydroepiandrosterone decreased and SHBG increased significantly in both groups. When

comparing the effect of both treatments, only a more pronounced decrease in free androgen index was found in the

METOC group. Adding metformin slightly modified the treatment effect of COC, causing a more significant decrease

in the free androgen index but having no additional positive impact on lipids, insulin sensitivity, SHBG or

testosterone. The available data do not offer enough evidence to advocate the standard use of combined treatment in

PCOS. Whether the combination might be beneficial for specific subgroups of patients is of further interest.

(PubHealth.info Document ID: CONT1T 529-06)

PubHealth.info NOTE: The author(s) of this article titled, "The effect of combination therapy with metformin and

combined oral contraceptives (COC) versus COC alone on insulin sensitivity, hyperandrogenaemia, SHBG and lipids

in PCOS patients.", is(are) Cibula D; Fanta M; Vrbikova J; Stanicka S; Dvorakova K. The source of this article is

"Human Reproduction. 2004;20(1):180-184.". This article was published in 2004 in English language(s).

(PubHealth.info® Document ID: CONT1T 529-06. All rights reserved with PubHealth.info) PIN: 529

This article is peer-reviewed.

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