Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 2004

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Double-blind, randomized study comparing the effects of two monophasic oral

contraceptives containing ethinylestradiol (20 micrograms or 30 micrograms)

and levonorgestrel (100 micrograms or 150 micrograms) on lipoprotein

metabolism.

AUTHORS

Scharnagl H; Petersen G; Nauck M; Teichmann AT; Wieland H

SOURCE

Contraception. 2004 Feb;69(2):105-113.

ABSTRACT

The effects of two monophasic oral contraceptives containing ethinylestradiol 20µg in combination with

levonorgestrel 100µg (EE20/LNG100) or 30µg and 150µg (EE30/LNG150), respectively, on lipoprotein metabolism

was investigated in a double-blind, randomized study of 12 treatment cycles in healthy female volunteers. Total

triglycerides (+32% to +46%, p < 0.05 in comparison to baseline) increased significantly. Triglycerides were highest

after six cycles of treatment, decreasing thereafter. Total cholesterol (+1% to +7%), apolipoprotein (apo) B (+21% to

+29%) and low-density lipoprotein (LDL) cholesterol (+7% to +17%) increased slightly. High-density lipoprotein (HDL)

cholesterol decreased slightly (-11% and -5%), HDL triglycerides increased (+16% and +26%). Apo AI did not change

during the study, suggesting that the molar concentration of HDL particles did not change. Apo E (-23% to -14%)

decreased, and there was a transitory decrease of lipoprotein (a). Essentially, there was no difference regarding the

changes in lipoprotein metabolism between the two treatment groups. The effects of the two combinations of

ethinylestradiol and levonorgestrel on triglyceriderich lipoproteins appear less pronounced than those produced by

preparations containing third-generation progestins. It is not likely that the changes in lipoprotein metabolism brought

about by the two preparations will alter the risk of future cardiovascular disease in a clinically relevant fashion.

(PubHealth.info Document ID: CONT1T 527-06)

PubHealth.info NOTE: The author(s) of this article titled, "Double-blind, randomized study comparing the effects of

two monophasic oral contraceptives containing ethinylestradiol (20 micrograms or 30 micrograms) and levonorgestrel

(100 micrograms or 150 micrograms) on lipoprotein metabolism.", is(are) Scharnagl H; Petersen G; Nauck M;

Teichmann AT; Wieland H. The source of this article is "Contraception. 2004 Feb;69(2):105-113.". This article was

published in 2004 in English language(s). (PubHealth.info® Document ID: CONT1T 527-06. All rights reserved with

PubHealth.info) PIN: 527

This article is peer-reviewed.

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