Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 2004

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Depot testosterone with etonogestrel implants result in induction of

azoospermia in all men for long-term contraception.

AUTHORS

Brady BM; Walton M; Hollow N; Kicman AT; Baird DT

SOURCE

Human Reproduction. 2004;19(11):2658-2667.

ABSTRACT

Combined testosterone and progestogen preparations are a promising approach to male hormonal contraception. We

investigated the effect of s.c. etonogestrel with depot testosterone on spermatogenesis in normal men over a period

of 48 weeks. Fifteen healthy men received three s.c. 68mg etonogestrel implants. Testosterone pellets (400 mg) were

administered at 12 weekly intervals. Nine men completed 48 weeks of treatment. Four subjects chose to discontinue

after 6 months, one man withdrew from the study early for personal reasons and one was withdrawn due to illness.

Sperm concentrations of <1 x 10/6/ml were achieved in all men by 16 weeks of treatment. All men became

azoospermic, although the time to achieve this varied from 8 to 28 weeks. Azoospermia was maintained in eight of

the nine men treated for 48 weeks, one subject showing partial recovery from 40 weeks. Testosterone levels

remained in the physiological range throughout. Treatment did not result in weight gain, change in body composition

or decline in high-density lipoprotein cholesterol concentrations. The combination of three etonogestrel implants

with depot testosterone results in rapid and consistent suppression of spermatogenesis. This can be maintained for

up to 1 year and may therefore be a suitable approach for a long-acting male hormonal contraceptive. (PubHealth.info

Document ID: CONT1T 523-06)

PubHealth.info NOTE: The author(s) of this article titled, "Depot testosterone with etonogestrel implants result in

induction of azoospermia in all men for long-term contraception.", is(are) Brady BM; Walton M; Hollow N; Kicman

AT; Baird DT. The source of this article is "Human Reproduction. 2004;19(11):2658-2667.". This article was

published in 2004 in English language(s). (PubHealth.info® Document ID: CONT1T 523-06. All rights reserved with

PubHealth.info) PIN: 523

This article is peer-reviewed.

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