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PubHealth.info®
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based on abstracts of articles published on a variety of public health issues/topics,
particularly encompassing
population planning, disease prevention, maternal and child health,
and communicable and
non-communicable diseases (like HIV AIDS, malaria, etc) that are
affecting a significant portion of population in developing and
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countries. Here you can find abstracts of articles published on a variety of public health
topics under category "Contraception
(Birth Control) and Family Planning".
Contraception (birth control)
is a regimen of one or more actions, devices, or medications followed in
order to deliberately prevent or reduce the likelihood of a woman
becoming pregnant or giving birth. Therefore contraception is the
utilization of various and sundry surgical procedures, devices,
practices, agents, or drugs with the intention of preventing conception
or impregnation (pregnancy). Methods and intentions typically termed
birth control may be considered a pivotal ingredient to family
planning. Birth control is a controversial political and ethical
issue in many cultures and religions, and although it is generally less
controversial than abortion specifically. |
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| CATEGORY: |
Contraception (Birth Control) and Family Planning |
| Contraceptive efficacy of antimicrobial peptide Nisin: in vitro and in vivo |
| Aranha C; Gupta S; Reddy KV |
| Contraception. 2004 Apr;69(4):333-338. |
| Sexually transmitted infections and unplanned pregnancies present a great risk to the reproductive health of women. |
| Therefore, female-controlled vaginal products directed toward disease prevention and contraception are needed |
| urgently. In the present study, efforts were made to evaluate the contraceptive potential of Nisin. The effect of Nisin |
| on sperm motility was assessed under in vitro and in vivo conditions. The results showed that sperm motility was |
| completely inhibited with Nisin. The minimum effective concentration of Nisin required to immobilize sperm (80-100 |
| X 10(6)) in vitro within 20 s was found to be 50 µg in rat, 200 µg in rabbit and 300-400 µg in monkey and human. The |
| effect on sperm motility was observed to be dose- and time-dependent. Intravaginal administration of Nisin (200 µg) |
| before mating during proestrus-estrous transition phase caused complete arrest of sperm motility and blockage of |
| conception. Subacute toxicity studies in rats indicated that, repetitive intravaginal application of Nisin at the dose of |
| 200 µg for 14 consecutive days induced no abnormalities either in the length of estrous cycle or in the morphology of |
| vaginal epithelial cells. No histopathological abnormalities in vaginal tissue or any change in blood and serum |
| biochemical profiles were observed. Furthermore, no adverse effects were observed on subsequent reproductive |
| performance, neonate survival and development of pups. It is suggested that Nisin, with its antibacterial and |
| spermicidal activities, could be developed as a potent vaginal contraceptive for future use in humans. |
| (PubHealth.info Document ID: CONT1T 509-06) |
| PubHealth.info NOTE: The author(s) of this article titled, "Contraceptive efficacy of antimicrobial peptide Nisin: in |
| vitro and in vivo studies.", is(are) Aranha C; Gupta S; Reddy KV. The source of this article is "Contraception. 2004 |
| Apr;69(4):333-338.". This article was published in 2004 in English language(s). (PubHealth.info® Document ID: |
| CONT1T 509-06. All rights reserved with PubHealth.info) PIN: 509 |
| This article is peer-reviewed. |
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