Contraception (Birth Control) and Family Planning PubHealthInfo

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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 2004

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Contraception by Ushercell (cellulose sulfate) in formulation: duration of

effect and dose effectiveness.

AUTHORS

Anderson RA; Feathergill K; Diao X; Chany C 2d; Rencher WF

SOURCE

Contraception. 2004;70:415-422.

ABSTRACT

This study evaluated contraception by formulated Ushercell(tm), a uniquely high-molecular-weight form of cellulose

sulfate, in the rabbit. Variables included (1) dose effectiveness, (2) duration of effectiveness, and (3) formulation

excipients. Vaginally applied carboxymethyl-cellulose-based Ushercell(tm) gel is contraceptive. A 6% gel is active for

at least 18 h; partial activity is observed for at least 24 h. With an application-insemination interval of 0.5 h,

Ushercell(tm) as low as 0.1% is contraceptive. Contraception is incomplete with 2% Ushercell(tm) and an

application-insemination interval of 24 h. Ushercell(tm) formulations containing a relatively high concentration of

Carbopol are ineffective contraceptives, whether the gel is applied before insemination or is premixed with

spermatozoa before insemination. Contraceptive activity is restored in Ushercell(tm) formulations with lower Carbopol

content. This study shows that formulated Ushercell(tm) is an effective, long-lasting contraceptive and, hence, is

bioavailable when vaginally applied. Activity is dependent on the type and relative concentration of formulation

excipients. These data support a projected successful outcome of further clinical trials. (PubHealth.info Document

ID: CONT1T 506-06)

PubHealth.info NOTE: The author(s) of this article titled, "Contraception by Ushercell (cellulose sulfate) in

formulation: duration of effect and dose effectiveness.", is(are) Anderson RA; Feathergill K; Diao X; Chany C 2d;

Rencher WF. The source of this article is "Contraception. 2004;70:415-422.". This article was published in 2004 in

English language(s). (PubHealth.info® Document ID: CONT1T 506-06. All rights reserved with PubHealth.info) PIN:

506

This article is peer-reviewed.

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