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PubHealth.info® (a subsidiary of PakMed) presents scientific information mainly based on abstracts of articles published on a variety of public health issues/topics, particularly encompassing population planning, disease prevention, maternal and child health, and communicable and non-communicable diseases (like HIV AIDS, malaria, etc) that are affecting a significant portion of population in developing and developed countries. Here you can find abstracts of articles published on a variety of public health topics under category "Contraception (Birth Control) and Family Planning". Contraception (birth control) is a regimen of one or more actions, devices, or medications followed in order to deliberately prevent or reduce the likelihood of a woman becoming pregnant or giving birth. Therefore contraception is the utilization of various and sundry surgical procedures, devices, practices, agents, or drugs with the intention of preventing conception or impregnation (pregnancy). Methods and intentions typically termed birth control may be considered a pivotal ingredient to family planning. Birth control is a controversial political and ethical issue in many cultures and religions, and although it is generally less controversial than abortion specifically.

YEAR: 1998

CATEGORY: Contraception (Birth Control) and Family Planning

TITLE

Cerebral thrombosis and oral contraceptives: a case-control study.

AUTHORS

Lidegaard O; Kreiner S

SOURCE

CONTRACEPTION. 1998 May;57(5):303-14.

ABSTRACT

The impact of oral contraceptive (OC) use on the risk of cerebral thromboembolic attack (CTA) is under investigation

in an ongoing case-control study in Denmark. Reported in this paper are initial findings related to 219 women 15-44

years of age listed in the Danish National Patient Register in 1994-95 with a diagnosis of thrombotic stroke or

transitory cerebral ischemic attack and 1041 healthy age-matched controls drawn from the Central Person Register.

After control for confounders, the odds ratios (ORs) of CTA compared with controls were 1.86 (95% confidence

interval (CI), 0.88-3.92) for current users of first-generation OCs containing 50 mcg of ethinyl estradiol or estrans, 2.37

(95% CI, 1.35-4.16) for second-generation OCs containing levonorgestrel or norgestimate, and 1.32 (95% CI, 0.78-

2.22) for third-generation OCs containing desogestrel or gestodene. Users of OCs with 50, 30-40, or 20 mcg of

ethinyl estradiol had ORs of 2.65 (95% CI, 1.11-6.34), 1.60 (95% CI, 1.05-2.43), and 1.59 (0.57-4.58), respectively. By

progestin component, the ORs were 1.37 (95% CI, 0.60-3.13) for estrans, 2.43 (95% CI, 1.40-4.21) for levonorgestrel,

7.09 (95% CI, 1.87-26.8) for norgestimate, 1.62 (95% CI, 0.72-3.63) for desogestrel, and 1.24 (95% CI, 0.67-2.30) for

gestodene. Compared with OC never-users, former users had an OR of CTA of 0.95 (95% CI, 0.66-1.51). The risk

was consistent across age bands and unaffected by duration of OC use. Overall, these findings suggest that CTA

risk is increased significantly in women who use OCs with 50 mcg of ethinyl estradiol and those containing second-

generation (but not third-generation) progestins. Similar analyses will be conducted of CTA cases diagnosed in

1996-98. (PubHealth.info Document ID: CONT1T 4586-06)

PubHealth.info NOTE: The author(s) of this article titled, "Cerebral thrombosis and oral contraceptives: a case-

control study.", is(are) Lidegaard O; Kreiner S. The source of this article is "CONTRACEPTION. 1998

May;57(5):303-14.". This article was published in 1998 in English language(s). (PubHealth.info® Document ID:

CONT1T 4586-06. All rights reserved with PubHealth.info) PIN: 4586

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